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Atorlip-ez ezetimibe , administered in combination with a 3-hydroxy-3-methylglutaryl-coenzyme a hmg-coa reductase inhibitor statin , is indicated as adjunctive therapy to diet for the reduction of elevated total-c, ldl-c, and apo b in patients with primary heterozygous familial and non-familial hyperlipidemia.
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Atovastatin is a slctiv, comptitiv inhibit3-hydoxy-3-mthylglutayl-conzym A (HMG-CoA) ductas, th at-limiting nzym that convts 3-HMG-CoA tmvalonat, a pcusstols, including cholstol. Cholstol and tiglycids (TG) ciculat in th bloodstam as pat lipopotin complxs. With ultacntiugation, ths complxs spaat inthigh-dnsity lipopotin (HDL), intmdiat-dnsity lipopotin (IDL), low-dnsity lipopotin (LDL) and vy-low-dnsity lipopotin (VLDL) actions. TG and cholstol in th liv a incopoatd intVLDL and lasd intth plasma dlivy tpiphal tissus. LDL is omd om VLDL and is catabolizd pimaily though th high-ainity LDL cpto.
Duc th isk non-atal MI duc th isk atal and non-atal stok duc th isk vasculaization pocdus duc th isk hospitalization CH duc th isk angina.
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Patints with a histoy cnt myocadial inaction (MI), cnt stok, stablishd piphal atial disas, clopidogl has bn shown tduc th at a combind ndpoint nw ischmic stok (atal not), nw MI (atal not), and oth vascula dath.
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atorlip is also used in patients with clinically evident chd to reduce the risk of non-fatal myocardial infarction reduce the risk of fatal and non-fatal stroke reduce the risk for revascularization procedures reduce the risk of hospitalization for chf reduce the risk of angina atorlip is also used for the treatment of hypercholesterolemia.