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Because of the wide variation in the absorption and distribution of tricyclic antidepressants in body fluidsit is difficult to directly correlate plasma levels and therapeutic effectHoweverdetermination of plasma levels may be useful in identifying patients who appear to have toxic effects and may have excessively high levelsor those in whom lack of absorption or noncompliance is suspectedBecause of increased intestinal transit time and decreased hepatic metabolism in elderly patientsplasma levels are generally higher for a given oral dose of amitriptyline hydrochloride than in younger patients.

Amitriptyline inhibits the membrane pump mechanism responsible for uptake of norepinephrine and serotonin in adrenergic and serotonergic neuronsPharmacologically this action may potentiate or prolong neuronal activity since reuptake of these biogenic amines is important physiologically in terminating transmitting activityThis interference with the reuptake of norepinephrine and/or serotonin is believed by some to underlie the antidepressant activity of amitriptyline.

Before taking amitriptylinetell your doctor or pharmacist if you are allergic to itor to other tricyclic antidepressantssuch as nortriptylineor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.

Tell your doctor if your condition persists or worsenssuch as your feelings of sadness get worseor you have thoughts of suicide

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