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Continued use of cyclophosphamide is contraindicated in patients with severely depressed bone marrow functionCyclophosphamide is contraindicated in patients who have demonstrated a previous hypersensitivity to itSee WARNINGS and PRECAUTIONS

Alopecia occurs in patients treated with cyclophosphamideSkin rash occurs occasionally in patients receiving the drugPigmentation of the skin and changes in nails can occur.

Hypersensitivitysee CONTRAINDICATIONSMyelosuppressionImmunosuppressionBone Marrow Failureand Infectionssee WARNINGS AND PRECAUTIONSUrinary Tract and Renal Toxicitysee WARNINGS AND PRECAUTIONSCardiotoxicitysee WARNINGS AND PRECAUTIONSPulmonary Toxicitysee WARNINGS AND PRECAUTIONSSecondary Malignanciessee WARNINGS AND PRECAUTIONSVeno-occlusive Liver Diseasesee WARNINGS AND PRECAUTIONSEmbryo-Fetal Toxicitysee WARNINGS AND PRECAUTIONSReproductive System Toxicitysee WARNINGS AND PRECAUTIONS and Use In Specific PopulationsImpaired Wound Healingsee WARNINGS AND PRECAUTIONSHyponatremiasee WARNINGS AND PRECAUTIONS

This drug passes into breast milk and may harm a nursing infantBreast-feeding while using this drug is not recommendedConsult your doctor before breast-feeding.

Skin and Subcutaneous Tissuetoxic epidermal necrolysisStevens-Johnson syndromeerythema multiformepalmar-plantar erythrodysesthesia syndromeradiation recall dermatitistoxic skin eruptionurticariadermatitisblisterprurituserythemanail disorderfacial swellinghyperhidrosis.

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