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REVIA is a pure opioid antagonistIt does not lead to physical or psychological dependenceTolerance to the opioid antagonist effect is not known to occur.

Patients receiving opioid analgesicsPatients currently dependent on opioidsincluding those currently maintained on opiate agonistse.gmethadoneor partial agonistse.gbuprenorphinePatients in acute opioid withdrawalsee WARNINGSAny individual who has failed the naloxone challenge test or who has a positive urine screen for opioidsAny individual with a history of sensitivity to REVIA or any other components of this productIt is not known if there is any cross-sensitivity with naloxone or the phenanthrene containing opioids.

Treatment in patients who have been able to abstain from alcohol in outpatient settings before treatment initiation.

Naltrexone may cause liver damage when taken in large dosesIt is not likely that naltrexone will cause liver damage when taken in recommended dosesTell your doctor if you have or have ever had hepatitis or liver diseaseIf you experience any of the following symptomsstop taking naltrexone and call your doctor immediatelyexcessive tiredness,unusual bleeding or bruisingloss of appetitepain in the upper right part of your stomach that lasts more than a few dayslight-colored bowel movements,dark urineor yellowing of the skin or eyes.

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