The use of progestin with estrace may lower the risk of acquiring uterine cancer.

Information about Estrace.

Using estrogen alone may increase your chance of getting cancer of the uteruswombReport any unusual vaginal bleeding right away while you are using ESTRACEVaginal bleeding after menopause may be a warning sign of cancer of the uterusYour healthcare provider should check any unusual vaginal bleeding to find out the causeDo not use estrogens alone or with progestins to prevent heart diseaseheart attacksstrokesor dementiadecline in brain functionUsing estrogens alone or with progestins may increase your chances of getting heart attacksstrokesbreast cancerblood clotsand dementiaYou and your healthcare provider should talk regularly about whether you still need treatment with ESTRACE vaginal cream.

The distribution of exogenous estrogens is similar to that of endogenous estrogensEstrogens are widely distributed in the body and are generally found in higher concentrations in the sex hormone target organsEstrogens circulate in the blood largely bound to sex hormone binding globulinSHBGand albumin.

Get emergency help immediately if any of the following symptoms of overdose occur while taking estradiol:

The Women’s Health InitiativeWHIestrogen-alone substudy reported increased risks of stroke and deep vein thrombosisDVTin postmenopausal women with daily oral conjugated estrogensCEaloneThe WHI estrogen-plus-progestin substudy reported increased risks of DVTpulmonary embolismstrokeand myocardial infarction in postmenopausal women with daily oral CE combined with medroxyprogesterone acetateMPAIn the absence of comparable datathese risks should be assumed to be similar for other dosage forms of estrogens.

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