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• Hepatic toxicity has occurred in patients with or without prior history of abnormal liver function.
• This precaution is based on preliminary results of animal research currently in progress that suggest a toxic interaction between inhaled ethylene dibromide and ingested disulfiram resulting in a higher incidence of tumors and mortality in rats.
• Geriatric Use A determination has not been made whether controlled clinical studies of disulfiram included sufficient numbers of subjects aged 65 and over to define a difference in response from younger subjects.
• The patient must be fully informed of the disulfiram-alcohol reaction.
• He should be warned to avoid alcohol in disguised forms, i.

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